Because Apple transitioned to and removed 32-bit app support starting with macOS Catalina, standard "Wine 2.0" builds will not work on modern systems. You should look for "Wine CX" builds or tools like Whisky that handle the translation between Intel (x86) and Apple (ARM) architectures.
This version significantly improved support for Microsoft Office 2013 , allowing Mac users to run the suite without a full Windows installation. Wine for Mac 2.0
A modern, sleek interface built on top of Apple’s Game Porting Toolkit, designed specifically for running Windows games on Apple Silicon. Pro-Tip for Mac Users Because Apple transitioned to and removed 32-bit app
A polished, paid version of Wine developed by CodeWeavers , which offers easy installation and technical support. A modern, sleek interface built on top of
The release of Wine 2.0 was significant for Mac users because it introduced over 6,600 individual changes, focusing on better performance and compatibility.
Improved scaling and rendering for high-resolution Retina displays, making Windows apps look less "blurry" on modern MacBooks. How to use Wine on Modern macOS
It solidified the ability to run 64-bit applications on macOS, which became critical as Apple phased out 32-bit support.