The combat system is deep and complex, with a focus on positioning, terrain, and exploiting enemy weaknesses. Players can choose from a variety of character classes, each with unique abilities and playstyles.

The game takes place in the Koronus Expanse, a vast region of space on the edge of the Imperium of Man, where players assume the role of a Rogue Trader, a unique individual with the freedom to explore, trade, and wage war in a lawless frontier. The story is heavily focused on player choice and consequence, with multiple branching paths and endings.

The setting is richly detailed, with a palpable sense of grit and despair that permeates every aspect of the game. From the crumbling infrastructure of abandoned planets to the ornate, gothic architecture of Imperial strongholds, the world of Rogue Trader is a bleak and unforgiving place.