The system described in the 2026 publications (often referred to as the ULTRA system) provides an unprecedented combination of field-of-view (FOV) and depth. Multi-scale in vivo neuronal imaging.
It allows researchers to visualize brain structures spanning from superficial layers down to 900 μm depth in a single study. VAM_GS.Qiao.2.var
Ultra-wide-field, deep, adaptive two-photon microscopy for ... - PMC The system described in the 2026 publications (often
The system produces large, dense 3D datasets requiring advanced denoising, sometimes utilizing "zero-shot learning" methods to process weak fluorescence signals without pre-training on existing data. Summary of Performance (2026) Capability Field of View Imaging Depth Spatial Range Volume Coverage Resolution Cellular resolution Ultra-wide-field, deep, adaptive two-photon microscopy for
Effective imaging up to 900 μm in the mouse brain, crucial for studying deep cortical layers.
Experiments have shown its capability to study both morphology (structural) and neuronal activity (functional) in mouse brains. 4. Implementation and Data Handling