Topic 52: Cervical Disease And Neoplasia 🆓

The transformation of normal cervical epithelium into a neoplastic state typically occurs at the transformation zone—the area where glandular columnar cells meet squamous cells. Persistent infection with high-risk HPV types, most notably HPV 16 and 18, is the necessary precursor for nearly all cervical cancers. These viruses integrate into the host genome, leading to the overexpression of oncoproteins E6 and E7, which inactivate tumor suppressor proteins p53 and Rb, respectively. This disruption of the cell cycle allows for the accumulation of genetic mutations and the eventual development of Cervical Intraepithelial Neoplasia (CIN). Screening and Diagnosis

Molecular assays detect the presence of high-risk viral DNA. Topic 52: Cervical Disease and Neoplasia

The Pap smear identifies morphological changes in exfoliated cells. The transformation of normal cervical epithelium into a

This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more This disruption of the cell cycle allows for