Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power
The study highlights that membrane binding involves a cooperative effort of multiple domains.
It tethers vesicles to the plasma membrane, facilitating sound encoding. tm,cc,jp
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds. The protein utilizes several C2 domains (C2A-C2F) to
The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane"). This guide focuses on the molecular mechanism of
This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs.