Peter's retirement is short-lived. After an inspiring talk with Aunt May about the "hero in all of us," and seeing Doc Ock kidnap Mary Jane, Peter realizes he cannot ignore his responsibility. His powers return as his will to protect those he loves is restored.
His grades at university are slipping because he can't focus on his studies. Spider-Man 2 (2004)
Under this immense psychological pressure, Peter begins to lose his superpowers. His "resolve isn't clear," causing his webs to fail and his wall-crawling abilities to vanish. Exhausted, he famously leaves his suit in a trash can, deciding he is "Spider-Man no more". The Rise of Doctor Octopus Peter's retirement is short-lived
Two years after becoming Spider-Man, 20-year-old Peter Parker's life is in shambles. His dedication to fighting crime has led to: His grades at university are slipping because he
He is fired from Joe’s Pizza for late deliveries.
In the final confrontation at Doc Ock’s waterfront lab, Peter reveals his identity to Otto to appeal to his humanity. Otto regains control of his mechanical arms and chooses to sacrifice himself, drowning his unstable fusion reactor in the river to save the city. Mary Jane finally learns that Peter is Spider-Man, and despite the danger, she chooses to be with him, ending the story on a bittersweet note of hope and sacrifice.
His best friend, Harry Osborn, hates Spider-Man for the death of his father, and Mary Jane Watson—the love of Peter's life—is engaged to John Jameson.