Grey's Anatomy Season 3, Episode 14, "Wishin' and Hopin'," originally aired on February 1, 2007, featuring a medical crisis based on the Gloria Ramirez case where a patient's blood turns toxic, causing staff to collapse. The episode also highlights a period of lucidity for Meredith's mother, Ellis Grey, who harshly confronts her daughter before her Alzheimer's symptoms return. Details on the episode's plot, including George and Callie's elopement and the opening of the Denny Duquette Memorial Clinic, can be found at the Grey's Anatomy Universe Wiki. Wishin' and Hopin' | Grey's Anatomy Universe Wiki | Fandom