Nfl San Francisco 49ers Vs Arizona Cardinals Instant

Arizona handed the 49ers a humiliating 47–24 loss, which sealed San Francisco's "disastrous" 6–11 season and secured them the No. 11 pick in the draft. Kyler Murray threw four touchdowns in the blowout.

According to the 49ers–Cardinals rivalry history , the series is defined by long streaks of dominance. San Francisco 49ers Arizona Cardinals 38 Wins Longest Win Streak 5 Games (Three times) 8 Games (2015–2018) Largest Victory 50–14 (2003) 47–7 (2015) Playoff Meetings Key Rivalry Trends NFL San Francisco 49ers vs Arizona Cardinals

The 49ers regained momentum in the 2025 campaign, winning both matchups: Arizona handed the 49ers a humiliating 47–24 loss,

The Cardinals overcame a halftime deficit to stun the 49ers 24–23 at Levi's Stadium. This game set a record for the hottest regular-season kickoff at the stadium at According to the 49ers–Cardinals rivalry history , the

The and San Francisco 49ers have a storied NFC West rivalry, with the 49ers currently leading the all-time series 38–31 . Recent Series Recap (2024–2025 Seasons)