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If you are describing women from the geographical location, you typically use the (no article) before the island's name: "Mature women of Lesbos" (Most common and formal) "Mature Lesbos women" (Using the location as a modifier) 2. Referring to Sexual Identity
The use of a proper article for the phrase depends on whether you are referring to the Greek island or the identity of the women . 1. Referring to the Island mature women lesbos
(Informal/slang, often used without an article in searches or casual titles) Grammar Guidelines Lesbos: a Greek island big enough for two - BBC If you are describing women from the geographical
If the term is being used as a shortened form of "lesbian" (slang or colloquial), it functions as a noun or adjective: (Standard English) mature women lesbos