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The PDB 4NYW crystal structure of the CREBBP bromodomain acts as a critical blueprint for developing selective chemical probes to treat cancers and diseases associated with gene regulation. By identifying unique molecular features, such as the specific binding pocket architecture, this structural data enables the design of drugs that avoid off-target effects on similar bromodomain families. Read the full study on bromodomain selectivity at CORE .

Selectivity on-target of bromodomain chemical probes ... - PMC https://1cloudfile.com/4Nyw