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Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis

The PI3K/AKT/mTOR signaling axis is one of the most frequently dysregulated pathways in human disease. AKT acts as a central hub, receiving signals from receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs). Upon recruitment to the plasma membrane via its PH domain, AKT is activated by phosphorylation at T308 and S473. 2. Isoform-Specific Functions File: AKT_collection_compressed_2022-11-20.zip ...

: The primary regulator of insulin-dependent glucose uptake in muscle and adipose tissue. File: AKT_collection_compressed_2022-11-20.zip ...

We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers File: AKT_collection_compressed_2022-11-20.zip ...