The condition stems from a in the GNAS gene . This mutation is not inherited from parents but occurs spontaneously during early embryonic development.
Fibrous dysplasia is categorized by how many bones it affects: fibrous dysplasia of bone
A triad of polyostotic FD, café-au-lait skin spots (often with jagged "Coast of Maine" borders), and hyperfunctioning endocrine issues like precocious puberty. Symptoms and Complications The condition stems from a in the GNAS gene
Affects a single bone. It accounts for about 70-80% of cases and is often asymptomatic until discovered incidentally on an X-ray. increasing cAMP levels.
Symptoms vary widely based on the location and extent of the lesions: Fibrous Dysplasia - StatPearls - NCBI Bookshelf
The mutation leads to continuous activation of the Gsα protein, increasing cAMP levels.