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The 2021 French National Society of Coloproctology (SNFCP) consensus advocates a multimodal approach to Crohn’s disease-related perianal fistulas (CDPF), prioritizing surgical drainage, anti-TNF therapy, and sphincter preservation. Key updates highlight advanced closure techniques like mesenchymal stem cell injections, LIFT procedures, and laser therapy, while emphasizing patient-reported quality of life over radiological healing alone. For more details, consult the 2021 SNFCP guidelines. This is for informational purposes only