Download Cerebral Amyloid Angiopathy Criteria The Next Generation Pdf Apr 2026

The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria

: Specific patterns of white matter damage. Clinical Significance The "next generation" of cerebral amyloid angiopathy (CAA)

: The minimum age for applying the criteria has been lowered from 55 to 50 years . Clinical Significance : The minimum age for applying

The v2.0 criteria significantly increase diagnostic sensitivity—capturing more true cases without losing specificity—by broadening the biological markers recognized by MRI. Multiple separate foci of siderosis can now qualify

: While lobar intracerebral hemorrhage (ICH) and microbleeds remain central, cortical superficial siderosis (cSS) and convexity subarachnoid hemorrhage are now prioritized. Multiple separate foci of siderosis can now qualify a patient for a "probable CAA" diagnosis on their own.

The Boston criteria version 2.0 for cerebral amyloid angiopathy