: In oncology research, certain microRNAs like miR-196a2 are described as having a "double mature strand" (a 5′-end and a 3′-end strand). Studies suggest that polymorphisms in these strands can influence cancer risk.

: Research into plant reproduction sometimes identifies "double mature embryo sacs" in ovules, which can complicate genetic interpretations. Agriculture Intracranial double teratomas - ScienceDirect.com

In the spirits industry, "double mature" refers to aging a liquid in one type of cask and then transferring it to a different cask type to add a second layer of flavor.

: Pierre Ferrand produces a "Reserve Double Mature" cognac that is finished in Banyuls casks after its initial aging. Scientific and Medical Research