: A more chronic form where a depressed mood lasts for at least two years. Theories of Pathogenesis
Major depressive disorder (MDD) is a chronic psychiatric condition characterized by persistent sadness, loss of interest (anhedonia), and physical symptoms that significantly impair daily life. By 2030, the World Health Organization projects it will be the leading cause of global disease burden. depressive disorder
: Significant changes in appetite or weight, sleep disturbances (insomnia or hypersomnia), and psychomotor agitation or retardation. : A more chronic form where a depressed
