Complexation by Carboxylated Pillar[6]arene for Decreasing the Cytotoxicity of Nitrogen Mustard
Host–Guest Formulation of Carboxylatopillar[6]arene with Ergothioneine for the Combinational Therapy of Paraquat Poisoning
This research explores "competitive release," where CP6A carries a drug and only releases it when it encounters specific natural markers (like spermine) found in high levels in cancer cells.
Reducing the toxicity of nitrogen mustard on normal cells while enhancing its effect against spermine-overexpressed tumors. 3. Antidote and Poisoning Treatment
Complexation of specific residues by carboxylatopillar[6]arene: A general strategy to counteract enzymatic degradation for enhancing the metabolic stability of peptides
CP6A has also been studied as a "molecular container" to treat severe poisoning by trapping toxins while simultaneously releasing helpful antioxidants.
Depending on your specific area of interest, here are three highly relevant and helpful papers regarding its applications: 1. Drug Stabilization and Protease Resistance