DNA methylation typically involves the addition of a methyl group to cytosine bases in CpG dinucleotides. These modifications act as a regulatory layer that can "silence" genes without changing the underlying DNA sequence. The CARDIA Study - American Heart Association Journals
Association analysis between genome-wide DNA methylation (DNAm) and health outcomes—often termed (EWAS)—identifies epigenetic markers that correlate with disease risk, environmental exposures, and physiological traits. Unlike genetic variants, DNA methylation is dynamic, reflecting the interplay between an individual's genotype and their environment over time. Core Mechanisms and Functions Association analysis between genome-wide DNA me...