Extensive changes in the cell's proteins (the proteome) and gene expressions (the transcriptome) effectively "quench" the signals that should trigger the virus to reactivate.
Researchers found that a large portion of latently infected T cells are "activation inert." Essentially, the virus doesn't just hide; it sits within a cellular environment that has been significantly rewired to ignore typical "wake-up" signals like TCR/CD3 stimulation. Key Takeaways: 8137 epub
This research shifts the focus from just the virus to the , offering a roadmap for future HIV cure strategies. Extensive changes in the cell's proteins (the proteome)
The study introduces the idea of "transcriptomic noise"—stochastic (random) changes in gene expression that act as a threshold, preventing the virus from being "tripped" into an active state. the virus doesn't just hide