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Mutations or dysregulation of CLIC5 are associated with several pathologies:

The gene, identified by the Entrez Gene ID 53405 , encodes a member of the chloride intracellular channel (CLIC) family. Unlike traditional ion channels, CLIC proteins are "metamorphic," existing in both soluble and membrane-bound forms. CLIC5 is critical for maintaining the structural integrity of specialized cellular extensions, particularly in the inner ear and the kidneys. 2. Structural and Functional Mechanism 53405.rar

CLIC5 is essential for the formation and maintenance of hair cell stereocilia . Deficiencies in this gene are linked to progressive hearing loss, as the stereocilia fail to maintain their rigid, ladder-like structure necessary for sound transduction. Mutations or dysregulation of CLIC5 are associated with

While its primary role often appears structural, it can insert into membranes to regulate chloride ion flow, affecting cellular volume and pH. While its primary role often appears structural, it

RAR files are usually safe to use. But just like regular files, compressed files (RAR or ZIP) can also contain viruses or malware. CLIC5 chloride intracellular channel 5 [ (human)] - NCBI

The CLIC5 gene (53405) is more than a simple ion channel; it is a vital regulator of cellular morphology. By bridging the gap between the membrane and the cytoskeleton, it ensures the functionality of some of the body's most delicate sensory and filtration systems.

1. Introduction