24227.rar

A version of the manuscript is also available through PMC (National Library of Medicine) .

Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis Authors: Andrea Janesick, Bruce Blumberg, and others. 24227.rar

The paper explores how retinoic acid (RA) signaling uses feedback loops to maintain stable levels of Vitamin A metabolites, specifically examining the role of Retinoic Acid Receptors (RARs) and enzymes like Cyp26. Content Summary A version of the manuscript is also available

It discusses the role of Retinoic Acid Response Elements (RAREs) in promoters as sensors that modulate the expression of retinoid-related genes. 24227.rar

The paper investigates how excess RA triggers its own degradation (via Cyp26 enzymes) and how depletion leads to compensatory receptor expression.