The family's fortune was built by the late patriarch, (1923–2011), who turned the Bavaria Brewery into a national monopoly. In 2005, he executed a landmark deal, trading Bavaria for a 15% stake in SABMiller , which later merged with Anheuser-Busch InBev (AB InBev). Julio Mario Santo Domingo Jr.

The Santo Domingo family is one of Latin America's most influential dynasties, with a multi-billion-dollar empire deeply rooted in Colombia’s history and the global beverage industry.