Each adenoma subtype was directly compared to normal tissue to identify unique methylation signatures.

the specific genes affected within those 122,348 regions? Find the original article for more detailed methodology?

Based on recent scientific literature from late 2025/early 2026, the number refers specifically to the total count of Differentially Methylated Regions (DMRs) identified in a comprehensive study of colorectal adenoma subtypes.

The study identified these 122,348 genomic regions as having significantly different methylation patterns (adding or removing methyl groups, which changes gene expression) between various colorectal adenoma (precancerous polyp) subtypes and normal tissue. 122,348. Hypermethylated regions (Gene silencing): 6,263. Hypomethylated regions (Gene activation): 116,050.

The study allowed for precise differentiation of molecular pathways that lead to colorectal cancer (CRC), reinforcing that distinct histological groups (SSL vs. TSA vs. VA) are driven by unique molecular machinery. If you are working on a similar research project,

Identifying such a large number of specific DMRs offers potential for developing highly accurate molecular diagnostics to classify polyp risk, potentially distinguishing between aggressive polyps and benign ones. 3. Comparison and Methodology

Here is a deep guide into this finding and its clinical significance. 1. Context: What Are the 122,348 DMRs?